1. Improvement of cognitive and social abilities, as well as an increase in risk taking behaviours and emotional control problemsChanges in emotional processing and emotion recognitionChanges of social reward mechanisms, less accuracy in facial emotion recognition, and worse mental healthIncreased emotional processing and perception behaviourSweating, hot flashes and sleep problemsReduction of cognitive abilitiesLess modulation of response to stimuli,  higher activation of the reward circuitReduction of cognitive abilities during menopause - 1B. Myelination and restructuration of the prefrontal cortex and parietal areaVariation of volumes of grey matter in the hippocampus, the amygdale and some lobes of the brainSuppression of endogenous sex hormonesDecrease in gray matter, size increase in the pituitary glandDecrease of estradiol levels during menopausePossible increases on bilateral hippocampus volumes during MHTDecreased hormonal levels, increase in grey matter of certain areas, brain rejuvenationInteraction between estradiol receptors with brain-derived neurotrophic factors

2. Improvement of cognitive and social abilities, as well as an increase in risk taking behaviours and emotional control problemsChanges in emotional processing and emotion recognitionChanges of social reward mechanisms, less accuracy in facial emotion recognition, and worse mental healthIncreased emotional processing and perception behaviourSweating, hot flashes and sleep problemsReduction of cognitive abilitiesLess modulation of response to stimuli,  higher activation of the reward circuitReduction of cognitive abilities during menopause - 2B. Myelination and restructuration of the prefrontal cortex and parietal areaVariation of volumes of grey matter in the hippocampus, the amygdale and some lobes of the brainSuppression of endogenous sex hormonesDecrease in gray matter, size increase in the pituitary glandDecrease of estradiol levels during menopausePossible increases on bilateral hippocampus volumes during MHTDecreased hormonal levels, increase in grey matter of certain areas, brain rejuvenationInteraction between estradiol receptors with brain-derived neurotrophic factors

3. Improvement of cognitive and social abilities, as well as an increase in risk taking behaviours and emotional control problemsChanges in emotional processing and emotion recognitionChanges of social reward mechanisms, less accuracy in facial emotion recognition, and worse mental healthIncreased emotional processing and perception behaviourSweating, hot flashes and sleep problemsReduction of cognitive abilitiesLess modulation of response to stimuli,  higher activation of the reward circuitReduction of cognitive abilities during menopause - 3B. Myelination and restructuration of the prefrontal cortex and parietal areaVariation of volumes of grey matter in the hippocampus, the amygdale and some lobes of the brainSuppression of endogenous sex hormonesDecrease in gray matter, size increase in the pituitary glandDecrease of estradiol levels during menopausePossible increases on bilateral hippocampus volumes during MHTDecreased hormonal levels, increase in grey matter of certain areas, brain rejuvenationInteraction between estradiol receptors with brain-derived neurotrophic factors

4. Improvement of cognitive and social abilities, as well as an increase in risk taking behaviours and emotional control problemsChanges in emotional processing and emotion recognitionChanges of social reward mechanisms, less accuracy in facial emotion recognition, and worse mental healthIncreased emotional processing and perception behaviourSweating, hot flashes and sleep problemsReduction of cognitive abilitiesLess modulation of response to stimuli,  higher activation of the reward circuitReduction of cognitive abilities during menopause - 4B. Myelination and restructuration of the prefrontal cortex and parietal areaVariation of volumes of grey matter in the hippocampus, the amygdale and some lobes of the brainSuppression of endogenous sex hormonesDecrease in gray matter, size increase in the pituitary glandDecrease of estradiol levels during menopausePossible increases on bilateral hippocampus volumes during MHTDecreased hormonal levels, increase in grey matter of certain areas, brain rejuvenationInteraction between estradiol receptors with brain-derived neurotrophic factors

5. Improvement of cognitive and social abilities, as well as an increase in risk taking behaviours and emotional control problemsChanges in emotional processing and emotion recognitionChanges of social reward mechanisms, less accuracy in facial emotion recognition, and worse mental healthIncreased emotional processing and perception behaviourSweating, hot flashes and sleep problemsReduction of cognitive abilitiesLess modulation of response to stimuli,  higher activation of the reward circuitReduction of cognitive abilities during menopause - 5B. Myelination and restructuration of the prefrontal cortex and parietal areaVariation of volumes of grey matter in the hippocampus, the amygdale and some lobes of the brainSuppression of endogenous sex hormonesDecrease in gray matter, size increase in the pituitary glandDecrease of estradiol levels during menopausePossible increases on bilateral hippocampus volumes during MHTDecreased hormonal levels, increase in grey matter of certain areas, brain rejuvenationInteraction between estradiol receptors with brain-derived neurotrophic factors

6. Improvement of cognitive and social abilities, as well as an increase in risk taking behaviours and emotional control problemsChanges in emotional processing and emotion recognitionChanges of social reward mechanisms, less accuracy in facial emotion recognition, and worse mental healthIncreased emotional processing and perception behaviourSweating, hot flashes and sleep problemsReduction of cognitive abilitiesLess modulation of response to stimuli,  higher activation of the reward circuitReduction of cognitive abilities during menopause - 6B. Myelination and restructuration of the prefrontal cortex and parietal areaVariation of volumes of grey matter in the hippocampus, the amygdale and some lobes of the brainSuppression of endogenous sex hormonesDecrease in gray matter, size increase in the pituitary glandDecrease of estradiol levels during menopausePossible increases on bilateral hippocampus volumes during MHTDecreased hormonal levels, increase in grey matter of certain areas, brain rejuvenationInteraction between estradiol receptors with brain-derived neurotrophic factors

7. Improvement of cognitive and social abilities, as well as an increase in risk taking behaviours and emotional control problemsChanges in emotional processing and emotion recognitionChanges of social reward mechanisms, less accuracy in facial emotion recognition, and worse mental healthIncreased emotional processing and perception behaviourSweating, hot flashes and sleep problemsReduction of cognitive abilitiesLess modulation of response to stimuli,  higher activation of the reward circuitReduction of cognitive abilities during menopause - 7B. Myelination and restructuration of the prefrontal cortex and parietal areaVariation of volumes of grey matter in the hippocampus, the amygdale and some lobes of the brainSuppression of endogenous sex hormonesDecrease in gray matter, size increase in the pituitary glandDecrease of estradiol levels during menopausePossible increases on bilateral hippocampus volumes during MHTDecreased hormonal levels, increase in grey matter of certain areas, brain rejuvenationInteraction between estradiol receptors with brain-derived neurotrophic factors

8. Improvement of cognitive and social abilities, as well as an increase in risk taking behaviours and emotional control problemsChanges in emotional processing and emotion recognitionChanges of social reward mechanisms, less accuracy in facial emotion recognition, and worse mental healthIncreased emotional processing and perception behaviourSweating, hot flashes and sleep problemsReduction of cognitive abilitiesLess modulation of response to stimuli,  higher activation of the reward circuitReduction of cognitive abilities during menopause - 8B. Myelination and restructuration of the prefrontal cortex and parietal areaVariation of volumes of grey matter in the hippocampus, the amygdale and some lobes of the brainSuppression of endogenous sex hormonesDecrease in gray matter, size increase in the pituitary glandDecrease of estradiol levels during menopausePossible increases on bilateral hippocampus volumes during MHTDecreased hormonal levels, increase in grey matter of certain areas, brain rejuvenationInteraction between estradiol receptors with brain-derived neurotrophic factors